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S. Satish ¹, G. Sankara Aditya Sarma ¹, B. Ashok Reddy ¹, V. Sai Kishore ¹

Affiliations
1 Bapatla College of Pharmacy, Bapatla, Guntur Dist-522415, A.P., IN

Abstract

The influence of Soapnut on the permeability of Eudragit RL100 films was studied with a view to develop a suitable rate controlling membranes for transdermal use. Dibutyl phthalate was incorporated at a concentration of 15% w/w of dry polymer as plasticizer. The dry free films were evaluated for various mechanical properties further the permeability characteristics of free films was studied using propranalol hydrochloride and diltiazem hydrochloride as model drugs. Both water vapour transmission and drug diffusion rate followed zero order kinetics. The soapnut powder showed a significant influence on the mechanical as well as permeability characteristics. This may be due to difference in the affinity of soapnut with the film former. From this study it was concluded that the plasticized free films of Eudragit RL100 prepared with soapnut can be used as rate controlling membranes to develop transdermal drug delivery systems.

Keywords

Soapnut, Eudragit RL100, Dibutyl Phthalate, Permeability, Diffusion.

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B. Ashok Reddy ¹, S. Satish ¹, G. Sankara ¹, Adithya Sarma ¹, V. Sai Kishore ¹

Affiliations
1 Bapatla College of Pharmacy, Bapatla -522101, IN

Abstract

The influence of solubility of drug in the dispersed phase (Acetone: Water Mixtures) employed in the preparation on the entrapment efficiency and drug release from ethyl cellulose microcapsules was studied. Propranolol hydrochloride was used as core and microcapsules were prepared by an emulsion solvent evaporation method. All the solvents gave discrete, large sized, free flowing spherical microcapsules. The microcapsules were evaluated for size analysis, drug content, microencapsulation efficiency, wall thickness, drug release characteristics, influence of solvent employed on entrapment efficiency and Propranolol hydrochloride release from microcapsules, surface characteristics. Propranolol hydrochloride release from the microcapsules, followed zero order kinetics and influenced by the size of the microcapsules and the solvent employed in their preparation. The Propranolol hydrochloride release rate from the microcapsules was found to be decreased with increased proportion of water in the dispersed phase. Among the solvents employed acetone: water mixture (92.5% v/v : 7.5% v/v) was found to be more suitable for slow release of Propranolol hydrochloride from ethyl cellulose microcapsules.

Keywords

Propranolol Hydrochloride, Microcapsules, Emulsion Solvent Evaporation, Entrapment Efficiency.

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